At Toronto's General Hospital, 14-year-old diabetic Leonard Thompson became on January 11, 1922 the first person to be treated with the
insulin drug, using a fetal calf pancreas extract. However, the ox extract was so impure, Thompson suffered a severe allergic reaction, and further injections were canceled. A second dose was injected twelve days later with an improved extract. This was completely successful in completely eliminating the glycosuria sign of diabetes.
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